Organovo and Roche Researchers Publish Data Demonstrating Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity
Using Organovo’s 3D bioprinted human liver tissues, researchers from
“This publication clearly shows the outstanding performance of Organovo’s 3D bioprinted human liver tissues when compared to traditional preclinical tests in replicating human drug response at the tissue level,” said Dr.
Drug-induced liver injury is a major cause of late-stage clinical failures and post-market drug withdrawals. Existing preclinical tests include conventional 2D cell culture models, which lack longevity and cannot replicate the complex cell-cell interactions and environment of human tissue. Animal models can miss compounds that are toxic in humans because of species variations and other factors.
“Organovo’s bioprinting technology creates an in vitro system comprising multiple liver cell types in a defined spatial architecture that can be used over time to gather both histopathological and biochemical data for preclinical toxicity testing,” explained Dr. Presnell. “Our durable and reproducible model can also be used to measure cell-type specific responses and investigate toxicity mechanisms to develop alternative solutions.”
Organovo’s 3D bioprinted human liver tissues are composed of patient-derived parenchymal (hepatocyte) and non-parenchymal (endothelial and hepatic stellate) cell populations. In addition, the Company’s 3D bioprinting technology creates tissues that are both spatially patterned and three-dimensional. This solution allowed researchers to perform histologic analyses in this study that revealed distinct intercellular hepatocyte junctions, CD31+ endothelial networks, and desmin-positive, smooth muscle actin-negative quiescent stellates. Unlike 2D cell cultures, Organovo’s tissues maintained metabolically relevant levels of ATP and albumin and drug-induced enzyme activity of cytochrome P450s for more than four weeks in culture.
Dr. Presnell concluded, “This data set clearly supports the use of Organovo’s 3D bioprinted human liver tissues in preclinical testing for drug-induced liver toxicity to potentially reduce the risk of toxic drugs reaching patients and avoid costly late-stage clinical failures.”
The publication entitled, “Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro,” was published online on
Organovo designs and creates functional, three-dimensional human tissues for use in medical research and therapeutic applications. The Company develops 3D human disease models through internal development and in collaboration with pharmaceutical and academic partners.
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