Organovo Collaborates With University of Virginia to Develop Bioprinted Tissues for Volumetric Muscle Loss Injury
VML injuries occur in military and civilian populations, often as a result of trauma and life-saving surgery. VML can also be caused by congenital or acquired diseases. When VML injury occurs, the muscle’s natural ability to regenerate cannot overcome the severe damage resulting in permanent functional and cosmetic deficits. There are limited treatments currently available for these patients, which include surgical options that are largely ineffective and have poor cosmetic outcomes. There remains a great need for improved therapies that provide a more complete approach to regeneration of the injured muscle.
“Collaborations that bring together Organovo’s 3D bioprinting platform and top-notch research serve as a catalyst for the development of innovative treatments that meet critical unmet needs," said Eric David, M.D., J.D., chief strategy officer and executive vice president of preclinical development, Organovo. “Combining the expertise in muscle regeneration of Dr. Christ’s lab and
The Christ lab has conducted extensive studies in regeneration and advancement of biomaterials. It is part of the
“Current treatment for volumetric muscle loss injury is limited to surgical transfers of the patient’s muscle from a healthy site to the injured site. However, these treatments are associated with poor engraftment of the transferred muscle and can cause death of tissue at the healthy site,” said Dr. Christ. “We believe with the use of Organovo’s 3D bioprinting technology we could quickly develop a more complex and physiologically relevant bioengineered muscle prototype for preclinical testing. Accomplishing this goal would be a huge step in accelerating the therapeutic applications of bioprinted muscle tissues and providing a much needed treatment to those suffering from volumetric muscle loss.”
The UVA collaboration is one of multiple 3D bioprinter placements that
Organovo designs and creates functional, three-dimensional human tissues for use in medical research and therapeutic applications. The Company develops 3D human tissue models through internal development and in collaboration with pharmaceutical, academic and other partners.
For 2017, the University was ranked the No. 2 best public university by
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